Welcome to Myers Laboratory


  

Data Repositories
BMI Chromosome 7
BMI Chromosome 13
Parkinson Disease Data
Huntington Disease Data
Pulmonary Disease Data
Metabolic Syndrome Data
Illumina Data

Publication Timeline
· Publication Timeline

Laboratory Studies
· GenePD (Parkinson Disease)
· HD Maps (Huntington's Disease)
· Human Obesity
· Family Heart Study
· Chronic Obstructive Pulmonary Disease

Databases
· ProtRepeater

Software
· HaploBuild

Site Statistics
We received
933711
page views since April 2005

  
Genomewide Association Study for Susceptibility Genes Contributing to Familial Parkinson Disease

Nathan Pankratz, Ph.D.*, Jemma B. Wilk, D.Sc.*, Jeanne C. Latourelle, M.S., Anita L. DeStefano, Ph.D., Cheryl Halter, M.S., Elizabeth W. Pugh, Ph.D., Kimberly F. Doheny, Ph.D., James F. Gusella, Ph.D., William C. Nichols, Ph.D., Tatiana Foroud, Ph.D., Richard H. Myers, Ph.D. and the PSG –PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories. Human Genetics 2008 Nov 6. [Epub ahead of print]

The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's Disease

Jeanne C Latourelle, Mei Sun, Mark F Lew, Oksana Suchowersky, Christine Klein, Lawrence I Golbe, Margery H Mark, John H Growdon, G Frederick Wooten, Ray L Watts, Mark Guttman, Brad A Racette, Joel S Perlmutter, Anwar Ahmed, Holly A Shill, Carlos Singer, Stefano Goldwurm, Gianni Pezzoli, Michela Zini, Marie H Saint-Hilaire, Audrey E Hendricks, Sally Williamson, Michael W Nagle, Jemma B Wilk, Tiffany Massood, Karen W Huskey, Jason M Laramie, Anita L DeStefano, Kenneth B Baker, Ilia Itin, Irene Litvan, Garth Nicholson, Alastair Corbett, Martha Nance, Edward Drasby, Stuart Isaacson, David J Burn, Patrick F Chinnery, Peter P Pramstaller, Jomana Al-hinti, Anette T Moller, Karen Ostergaard, Scott J Sherman, Richard Roxburgh, Barry Snow, John T Slevin, Franca Cambi, James F Gusella and Richard H Myers. BMC Medicine 2008, 6:32.

Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes

Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; The NHLBI Family Heart Study. Laramie JM, Wilk JB, Williamson SL, Nagle MW, Latourelle JC, Tobin JE, Province MA, Borecki IB, Myers RH. BMC Med Genet 2008, 9:46.

NYD-SP18 is associated with obesity in the NHLBI Family Heart Study

Wilk JB, Laramie JM, Latourelle JC, Williamson S, Nagle MW, Tobin JE, Leiendecker Foster C, Eckfeldt JH, Province MA, Borecki IB, Myers RH. International Journal of Obesity. 2008, 32:930-5.

Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study

J.E. Tobin, PhD, J.C. Latourelle, MS, M.F. Lew, MD, C. Klein, MD, O. Suchowersky, MD, H.A. Shill, MD, L.I. Golbe, MD, M.H. Mark, MD, J.H. Growdon, MD, G.F. Wooten, MD, B.A. Racette, MD, J.S. Perlmutter, MD, R. Watts, MD, M. Guttman, MD, K.B. Baker, PhD, S. Goldwurm, MD, G. Pezzoli, MD, C. Singer, MD, M.H. Saint-Hilaire, MD, A.E. Hendricks, BA, S. Williamson, BS, M.W. Nagle, BA, J.B. Wilk, DSc, T. Massood, BS, J.M. Laramie, PhD, A.L. DeStefano, PhD, I. Litvan, MD, G. Nicholson, MD, A. Corbett, MD, S. Isaacson, MD, D.J. Burn, MD, P.F. Chinnery, MD, P.P. Pramstaller, MD, S. Sherman, MD, J. Al-hinti, MD, E. Drasby, MD, M. Nance, MD, A.T. Moller, MD, K. Ostergaard, MD, PhD, R. Roxburgh, PhD, B. Snow, MD, J.T. Slevin, MD, F. Cambi, MD, J.F. Gusella, PhD, R.H. Myers, PhD Neurology 2008, 71:29-35.

HaploBuild: An algorithm to construct noncontiguous associated

Laramie JM, Wilk JB, DeStefano AL, Myers RH. HaploBuild: An algorithm to construct noncontiguous associated haplotypes in family-based genetic studies. Bioinformatics 2007, 23:2190-92.

Framingham Heart Study genome wide association: Results for pulmonary function measures.

Wilk JB, Walter RE, Laramie JM, Gottlieb DJ, O’Connor GT. Framingham Heart Study genome wide association: Results for pulmonary function measures. BMC Med Genet. 2007 Sep 19;8 Suppl 1:S8.

Risk factor studies of age-at-onset in a sample ascertained for Parkinson disease affected...

Wilk JB, Lash TL. Risk factor studies of age-at-onset in a sample ascertained for Parkinson disease affected sibling pairs: a cautionary tale. Emerg Themes Epidemiol. 2007 Apr 4;4(1):1 Pubmed

Secreted Modular Calcium-Binding Protein 2 Haplotypes are Associated with Pulmonary Function

Wilk JB, Herbert A, Shoemaker CM, Gottlieb DJ, Karamohamed S. Secreted Modular Calcium-Binding Protein 2 Haplotypes are Associated with Pulmonary Function. Am J Respir Crit Care Med. 2007 Mar 15;175(6):554-60.Pubmed

Sepiapterin reductase expression is increased in Parkinson's disease brain tissue

Tobin JE, Cui J, Wilk JB, Latourelle JC, Laramie JM, McKee AC, Guttman M, Karamohamed S, Destefano AL, Myers RH. Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. Brain Res. 2007 Mar 30;1139:42-7. Pubmed

Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study.

Wilk JB, Tobin JE, Suchowersky O, Shill HA, Klein C, Wooten GF, Lew MF, Mark MH, Guttman M, Watts RL, Singer C, Growdon JH, Latourelle JC, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Berg CJ, Sun M, Goldwurm S, Pezzoli G, Racette BA, Perlmutter JS, Parsian A, Baker KB, Giroux ML, Litvan I, Pramstaller PP, Nicholson G, Burn DJ, Chinnery PF, Vieregge P, Slevin JT, Cambi F, MacDonald ME, Gusella JF, Myers RH, Golbe LI. Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: the GenePD Study. Neurology. 2006 Dec 26;67(12):2206-10. Pubmed

Molecular diagnostics in sepsis: from bedside to bench

Molecular diagnostics in sepsis: from bedside to bench. Chung TP, Laramie JM, Meyer DJ, Downey T, Tam LH, Ding H, Buchman TG, Karl I, Stormo GD, Hotchkiss RS, Cobb JP. J Am Coll Surg. 2006 Nov;203(5):585-598. Pubmed

Reporting association to hypertension rare genotypes with protective effects or common genotypes...

Reporting association to hypertension rare genotypes with protective effects or common genotypes increasing risk. Wilk JB. Am J Hypertens. 2006 Nov;19(11):1166. Pubmed

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Kishikawa S, Li JL, Gillis T, Hakky MM, Warby S, Hayden M, Macdonald ME, Myers RH, Gusella JF. Neurobiol Dis. 2006 Nov;24(2):280-5.

Genetic analysis of the GRIK2 modifier effect in Huntington's disease

Genetic analysis of the GRIK2 modifier effect in Huntington's disease. Zeng W, Gillis T, Hakky M, Djousse L, Myers RH, MacDonald ME, Gusella JF. BMC Neurosci. 2006 Sep 7;7:62.

Genome-wide significance for a modifier of age at neurological onset ...

Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. Li JL, Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gomez-Tortosa E, Garcia CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djousse L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH. BMC Med Genet. 2006 Aug 17;7:71. Pubmed

QTL-specific genotype-by-smoking interaction and burden of calcified coronary atherosclerosis...

QTL-specific genotype-by-smoking interaction and burden of calcified coronary atherosclerosis: The NHLBI Family Heart Study. North KE, Carr JJ, Borecki IB, Kraja A, Province M, Pankow JS, Wilk JB, Hixson JE, Heiss G. Atherosclerosis. 2006 Sep 9;Pubmed

Considerations for genomewide association studies in Parkinson disease

Considerations for genomewide association studies in Parkinson disease. Myers RH. 2006 Jun;78(6):1081-2. Pubmed

Adrenergic receptor polymorphisms associated with resting heart rate: The HyperGEN Study.

Adrenergic receptor polymorphisms associated with resting heart rate: The HyperGEN Study. Wilk JB, Myers RH, Pankow JS, Hunt SC, Leppert MF, Freedman BI, Province MA, Ellison RC. Annals Human Genetics 2005; 69:1-9. Pubmed

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism

HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism. Seong IS, Ivanova E, Lee JM, Choo YS, Fossale E, Anderson M, Gusella JF, Laramie JM, Myers RH, Lesort M, MacDonald ME. Hum Mol Genet. 2005 Oct 1;14(19):2871-80. Pubmed

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Karamohamed S, Latourelle JC, Racette BA, Perlmutter JS, Wooten GF, Lew M, Klein C, Shill H, Golbe LI, Mark MH, Guttman M, Nicholson G, Wilk JB, Saint-Hilaire M, DeStefano AL, Prakash R, Tobin S, Williamson J, Suchowersky O, Labell N, Growdon BN, Singer C, Watts R, Goldwurm S, Pezzoli G, Baker KB, Giroux ML, Pramstaller PP, Burn DJ, Chinnery P, Sherman S, Vieregge P, Litvan I, Gusella JF, Myers RH, Parsian A. Neurology. 2005 Dec 13;65(11):1823-5. Pubmed

Heterozygosity for Parkin Mutation Influences Onset Age in Familial Parkinson’s Disease

Heterozygosity for Parkin Mutation Influences Onset Age in Familial Parkinson’s Disease. Sun M, Latourelle JC, Wooten GF, Lew MF, Klein C, Shill HA, Golbe LI, Mark MH, Racette BA, Perlmutter JS, Parsian A, Guttman M, Nicholson G, Xu G, Wilk JB, Saint-Hilaire MH, DeStefano AL, Prakash R, Williamson S, Suchowersky O, Labelle N, Growdon JH, Singer C, Watts RL, Goldwurm S, Pezzoli G, Baker KB, Pramstaller PP, Burn DJ, Chinnery PF, Sherman S, Vieregge P, Litvan I, Gillis T, MacDonald ME, Myers RH, Gusella JF. Arch Neurol 2006 Jun;63(6):826-32. Pubmed

Evidence for a Gene Influencing Heart Rate on Chromosome 5p13-14...

Evidence for a Gene Influencing Heart Rate on Chromosome 5p13-14 in a Meta-Analysis of Genome-Wide Scans from the NHLBI Family Blood Pressure Program. Jason M Laramie, Jemma B. Wilk , Steven C. Hunt, R. Curtis Ellison, Aravinda Chakravarti, Eric Boerwinkle, Richard H. Myers, BMC Medical Genetics, 2006, 7:17. Pubmed

  
Laboratory Personnel
Richard H Myers, PhD
Professor of Neurology

Jemma B Wilk, D.Sc
Assistant Professor

Jeanne Latourelle, MS
Project Manager

Sally Williamson, BS
Laboratory Technician

Tiffany Massood, BS
HD MAPS Study Coordinator

Audrey Hendricks, BA
Biostatistics Doctoral Student

Alexandra Dumitriu, BS
Bioinformatics Doctoral Student

Amanda Ying Wang, PhD
Biostatistics Masters Student

Chris Pacheco, PhD
Postdoctoral Researcher

Brian Brandler, BS
Laboratory Technician

Laboratory Alumni
Jason M Laramie, PhD

Jennifer Tobin, PhD

PubMed Search

Comments? Please contact Jason M Laramie
Page Generation: 0.208 Seconds